Substrate and method for measuring the electro-physiological properties of cell membranes
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United States of America Patent
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Oct 30, 2007
Grant Date -
Jan 8, 2004
app pub date -
Apr 17, 2003
filing date -
Apr 17, 2002
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Abstract
The present invention relates to a substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim, the rim being adapted to form a gigaseal upon contact with the cell membrane, The invention further provides a method of making such a substrate and method for analysing the electrophysiological properties of a cell membrane comprising a glycocalyx.
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