Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer
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United States of America Patent
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Oct 16, 2007
Grant Date -
Nov 25, 2004
app pub date -
Aug 23, 2002
filing date -
Aug 24, 2001
priority date (Note) -
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Abstract
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, the proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.
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