Recombinant A2-specific TNF.alpha.-specific antibodies

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United States of America Patent

PATENT NO 7276239
APP PUB NO 20060140949A1
SERIAL NO

11314941

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Abstract

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Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-.alpha. (TNF.alpha.) and are useful in vivo diagnosis and therapy of a number of TNF.alpha.-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

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CENTOCOR INCPENNSYLVANIA AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Daddona, Peter Menlo Park, CA 59 1835
Ghrayeb, John Thorndale, PA 68 2748
Knight, David Berwyn, PA 136 4318
Le, Junming Jackson Heights, NY 59 2500
Siegel, Scott Westborough, MA 47 1512
Vilcek, Jan New York, NY 54 2122

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