Mesoporous permeation layers for use on active electronic matrix devices
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United States of America Patent
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Sep 18, 2007
Grant Date -
Jul 28, 2005
app pub date -
Mar 16, 2005
filing date -
Dec 10, 2001
priority date (Note) -
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Abstract
The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array by treating the surface with a linker by vapor deposition and providing a polymerization solution that includes at least one monomer having a polymerizable moiety, a modified streptavidin, a surfactant or porogen, and a cross-linking agent. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker.
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