Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
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United States of America Patent
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Sep 11, 2007
Grant Date -
Jan 22, 2004
app pub date -
Mar 11, 2003
filing date -
Jan 5, 1998
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Abstract
The present invention provides a method for identifying a member of a mass-coded combinatorial library which is a ligand for biomolecule and assessing the effect of the binding of the ligand to the biomolecule. The mass-coded molecular library comprises compounds of the general formula XY.sub.n, wherein n is an integer from 2 to about 6, X is a scaffold and each Y is, independently, a peripheral moiety. The mass-coded combinatorial library is produced by reacting a scaffold precursor with a sufficient number of distant peripheral moiety precursors such that there exist at least about 250 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors.
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