Polymeric thiol-linked prodrugs employing benzyl elimination systems
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United States of America Patent
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Aug 28, 2007
Grant Date -
Aug 21, 2003
app pub date -
Nov 8, 2002
filing date -
Nov 9, 2001
priority date (Note) -
Expired
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Abstract
Thiol-linked polymeric prodrugs, methods of making and using the same are disclosed. The use of a sulfhydryl bond in combination with a benzyl elimination system results in the formation of prodrugs which can take advantage of plasma enzymes in vivo for regeneration of the parent molecule. A preferred prodrug in accordance with the invention is: ##STR00001## where S-MP is 6-mercaptopurine.
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