Stable warfarin sodium liquid formulation and method of making same
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United States of America Patent
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Aug 21, 2007
Grant Date -
Dec 28, 2006
app pub date -
Jun 14, 2006
filing date -
Jun 15, 2005
priority date (Note) -
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Abstract
A stable liquid composition comprising warfarin sodium, glycerin, an alcohol such as ethanol, and a pH buffer such as a phosphate buffer providing a pH above 7 is provided. The stability of the composition is characterized by the amount of warfarin sodium in the composition degraded after 1 month at room temperature, which is 5% or less. A method for preparing the composition and a method for providing an anti-coagulant therapy are also disclosed.
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