Inhibitory oligonucleotides targeted to Bcl-2
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United States of America Patent
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Aug 14, 2007
Grant Date -
Aug 5, 2004
app pub date -
Nov 14, 2003
filing date -
Nov 14, 2002
priority date (Note) -
Expired
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Abstract
Inhibitory oligonucleotides are disclosed which are targeted to three specific target regions and subsequences of the target regions found on nucleic acids encoding Bcl-2. These inhibitory oligonucleotides are generally of from about 8 to about 50 nucleotides in length. Specific preferred oligonucleotides are disclosed. The oligonucleotides of the invention may be incorporated into compositions such as pharmaceutical compositions, and may be used in methods for inhibiting the expression of Bcl-2 in a cell or tissue, methods for treating conditions susceptible to modulation of Bcl-2 expression in an organism, and methods for detecting nucleic acid encoding BCL-2.
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