Human p53 mutations and a genetic system in yeast for functional identification of human p53 mutations
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United States of America Patent
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Aug 14, 2007
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N/A
app pub date -
Jul 28, 2000
filing date -
Jul 30, 1999
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Expired
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Abstract
The present invention provides isolated polypeptides of human p53 that contain mutations. These mutations can be toxic mutations, supertransactivating mutations or tox-suppressor mutations. Further provided by the invention are methods of identifying toxic, supertransactivating, weak transactivating and tox-suppressor mutations as well as methods of identifying compounds that mimic the toxic, supertransactivating and tox-suppressor mutations in human p53. Also provided are methods of inducing toxicity in a cell by administering a polypeptide comprising a supertransactivating or a toxic mutation.
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