Integrin targeted imaging agents
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United States of America Patent
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Aug 14, 2007
Grant Date -
Mar 25, 2004
app pub date -
Jan 24, 2003
filing date -
Jan 24, 2002
priority date (Note) -
Expired
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Abstract
Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for .alpha..sub.v.beta..sub.3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
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