Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
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United States of America Patent
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Jul 31, 2007
Grant Date -
Dec 25, 2003
app pub date -
Dec 20, 2002
filing date -
Jun 15, 1998
priority date (Note) -
Expired
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Abstract
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
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