C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes
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United States of America Patent
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Jul 31, 2007
Grant Date -
Nov 17, 2005
app pub date -
Apr 26, 2005
filing date -
Apr 26, 2004
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Abstract
Compounds of the current invention relate to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. More specifically, compounds of the current invention relate to C-25 carbamate derivatives of rifamycin having another functional group or pharmacophore covalently attached to this position through a carbamate linkage. The resulting compounds exert their antimicrobial activity through a dual-function mechanism and therefore exhibit reduced frequency of resistance.
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