Peptides and derivatives thereof showing cell attachment, spreading and detachment activity
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United States of America Patent
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Jul 31, 2007
Grant Date -
Jun 15, 2006
app pub date -
Feb 9, 2006
filing date -
May 13, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL (SEQ ID NO:2) and EPDIM (SEQ ID NO:3) and derivatives thereof which promote the cell attachment activity through interaction with .alpha.3.beta.1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing .beta.ig-h3, wound healing, tissue regeneration and metastasis inhibition.
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