Antagonist peptides to VEGF receptor Flt-1
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United States of America Patent
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Jul 31, 2007
Grant Date -
Jul 14, 2005
app pub date -
Sep 12, 2001
filing date -
Sep 12, 2001
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Abstract
The present invention provides a polypeptide or a pharmacologically acceptable salt thereof comprising one or more, identical or different, amino acid sequences of A-W--H--X1-D-X2-X3-X4-W--W--X5-X6-X7-X8-B (the meaning of each symbol in the formula is defined in the description) and a pharmaceutical composition for treating an angiogenic disease such as a solid tumor comprising said polypeptide. The present invention also relates to a polynucleotide encoding the above-mentioned polypeptide and use of the polynucleotide in gene therapy.
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