Complex of hepatitis B virus-specific antigenic peptides associated with heat shock proteins and the application thereof
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United States of America Patent
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Jul 24, 2007
Grant Date -
Mar 11, 2004
app pub date -
Feb 27, 2001
filing date -
Aug 11, 2000
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Abstract
The present invention provides a kind of HBV-antigen bound to heat shock proteins (hsps) which comprises core antigen, surface antigen and polymerase antigen. The present invention also provides a complex of HBV antigen bound to heat shock protein gp96 and hsp78, as well as a method for preparing the complex. The complex includes a complex of gp96 and hsp78 non-covalently bound to antigenic polypeptide, as well as a fusion protein of both which results from covalent binding. Such complex can be used to prepare therapeutic vaccine for treating hepatitis B and primary hepatocellular carcinoma.
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