Rifamycin derivatives effective against drug-resistant microbes
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United States of America Patent
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Jul 24, 2007
Grant Date -
Nov 24, 2005
app pub date -
Jan 12, 2005
filing date -
Jan 13, 2004
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Abstract
Rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms are claimed in this invention. The inventive rifamycin derivatives are uniquely designed in that they have a rifamycin moiety covalently linked to a linker group through the C-3 carbon of the rifamycin moiety and the linker is, in turn covalently linked to a therapeutic moiety or antibacterial agent/pharmacophore. The therapeutic moiety can be a quinolone, an oxazolidinone, a macrolide, an aminoglycoside, a tetracycline core or a structure/pharmacophore associated with an antibacterial agent.
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