Purine analogs having HSP90-inhibiting activity
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United States of America Patent
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Jul 10, 2007
Grant Date -
Mar 3, 2005
app pub date -
Oct 30, 2002
filing date -
Oct 30, 2001
priority date (Note) -
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Abstract
Novel purine compounds of Formula I. ##STR00001## and tautomers, pharmaceutically acceptable salts, and prodrugs thereof, wherein X is S, S(O), or S(O).sub.2; and O is selected from alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl, and heterocyclic, all optionally substituted, are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.
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