Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
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United States of America Patent
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Jul 10, 2007
Grant Date -
Oct 12, 2006
app pub date -
May 17, 2006
filing date -
May 22, 2001
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Expired
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Abstract
Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
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