Treating anemia in subjects by administration of plasmids encoding growth hormone releasing hormone
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United States of America Patent
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Jul 10, 2007
Grant Date -
Mar 25, 2004
app pub date -
Dec 10, 2002
filing date -
Dec 11, 2001
priority date (Note) -
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Abstract
The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and method are useful for retarding the growth of the tumor, and retarding cachexia, wasting, anemia and other effects that are commonly associated in cancer bearing animals. Overall, the embodiments of the invention can be accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded. gene in the animal. For example, when such a nucleic acid sequence is delivered into the specific cells of the tissue specific constitutive expression is achieved.
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