Rifamycin imino derivatives effective against drug-resistant microbes

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United States of America Patent

PATENT NO 7238694
APP PUB NO 20050209210A1
SERIAL NO

11034279

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to rifamycin 3-iminomethylenyl (--CH.dbd.N--) derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. The claimed rifamycin derivative has a rifamycin moiety covalently linked to a linker through an iminomethylenyl (--CH.dbd.N--) group at the C-3 carbon of the rifamycin moiety and the linker is, in turn, covalently linked to a quinolone structure or its pharmacophore within the DNA gyrase and topoisomerase IV inhibitor family. The inventive rifamycins are novel and exhibit activity against both rifampin and ciprofloxacin-resistant microorganisms.

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Patent Owner(s)

Patent OwnerAddress
TENNOR THERAPEUTICS (SUZHOU) LIMITEDROOM 701 BUILDING B7 NO 218 XINGHU STREET SUZHOU INDUSTRIAL PARK SUZHOU JIANGSU 215123 215123

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ding, Charles Z Plano, TX 109 845
Harran, Susan Dallas, TX 17 131
Jin, Yafei Dallas, TX 10 90
Kim, In Ho Flower Mound, TX 147 602
Li, Jing Dallas, TX 1112 6098
Longgood, Jamie C Carrollton, TX 4 57
Ma, Zhenkun Dallas, TX 64 488
Minor, Keith P Dallas, TX 8 85

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