Orientation independent differential interference contrast microscopy technique and device

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United States of America Patent

PATENT NO 7233434
APP PUB NO 20050152030A1
SERIAL NO

11002834

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Abstract

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A method for performing differential interference contrast microscopy on a specimen includes collecting at least two images with illumination respectively having first and second beam-shear directions relative to a rotational orientation of the specimen, determining data associated with an intensity distribution of each of the collected images, and calculating values having a spatial distribution that is substantially independent of the rotational orientation of the specimen. A differential interference contrast microscope includes a beam-shearing assembly that includes a beam-shearing component. The beam-shearing assembly is configured to provide a variable shear vector without a movement of the beam-shearing component. A microscopy system can include the microscope and an imaging-control unit.

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Patent Owner(s)

Patent OwnerAddress
MARINE BIOLOGICAL LABORATORY7 MBL STREET WOODS HOLE MA 02543

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Shribak, Mykhailo Woods Hole, MA 7 137

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