Aryl N-cyanoguanidines and methods related thereto
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United States of America Patent
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Jun 12, 2007
Grant Date -
Aug 18, 2005
app pub date -
Jan 21, 2005
filing date -
Feb 27, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): ##STR00001## including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R.sub.1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.
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