Growth differentiation factor-9 regulatory sequences and uses therefor
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United States of America Patent
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Jun 5, 2007
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N/A
app pub date -
Mar 31, 1999
filing date -
Mar 31, 1999
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Expired
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Abstract
Isolated GDF-9 regulatory sequences are disclosed, as well as methods of using the sequences to modulate tissue-specific expression of genes. The GDF-9 regulatory sequences include, for example, enhancer and promoter elements that naturally drive transcription of GDF-9 in specific tissues. The GDF-9 regulatory sequences can be derived from the untranscribed upstream (e.g., first 10 kilobases) and downstream regions, and transcribed, untranslated regions of a GDF-9 gene.
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