(R/S) rifamycin derivatives, their preparations and pharmaceutical compositions
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United States of America Patent
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Jun 5, 2007
Grant Date -
Jan 26, 2006
app pub date -
Jul 21, 2005
filing date -
Jul 22, 2004
priority date (Note) -
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Abstract
Rifamycin derivatives having the following structure of general formula I (both hydroquinone and corresponding quinone (C.sub.1-C.sub.4) forms): ##STR00001## or its salts, hydrates or prodrugs thereof; wherein a preferred R.sub.1 comprises hydrogen or acetyl and a prefered R.sub.2 comprises hydrogen, methyl or other lower alkyls; wherein asterik (*) denotes the carbon bearing the chiral center, wherein absolute configuration is assigned as R or S. Methods of preparation of the aforementioned rifamycin derivatives are also described. The compounds exhibit antimicrobial activities, including activities against drug-resistant microorganisms.
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