Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4
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United States of America Patent
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May 29, 2007
Grant Date -
Sep 1, 2005
app pub date -
Apr 14, 2005
filing date -
Jul 21, 2000
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Expired
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Abstract
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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