Fibroblast growth factor (FGF23) nucleic acids
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United States of America Patent
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May 29, 2007
Grant Date -
Oct 24, 2002
app pub date -
Jul 10, 2001
filing date -
Jul 19, 2000
priority date (Note) -
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Abstract
The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.
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