Method for preparation of 2'-deoxy-2', 2'-difluoro-.beta.-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-.beta.-d-glucose as raw material
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United States of America Patent
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May 8, 2007
Grant Date -
Jan 5, 2006
app pub date -
Jul 1, 2004
filing date -
Jul 1, 2004
priority date (Note) -
Expired
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Abstract
The present invention provides a method for preparation of 2'-deoxy-2',2'-difluoro-.beta.-cytidine or pharmaceutically acceptable salt thereof, comprising starting from 1,6-anhydro-.beta.-D-glucose as raw material, oxidizing, and fluorinating to obtain 2-deoxy-2,2-difluoro-D-ribofuranose as intermediate. The 2'-deoxy-2',2'-difluoro-.beta.-cytidine was finally prepared from the intermediate of 2-deoxy-2,2-difluoro-D-ribofuranose. The method is simple in operation and has a high yield. The method can effectively be used in large-scale production.
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