Isophthalic acid derivatives as matrix metalloproteinase inhibitors

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United States of America Patent

PATENT NO 7214712
APP PUB NO 20060025396A1
SERIAL NO

11238502

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Abstract

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Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula ##STR00001## wherein: R.sup.1, R.sup.2, and R.sup.3 independently are hydrogen, halo, hydroxy, C.sub.1 C.sub.6 alkyl, C.sub.1 C.sub.6 alkoxy, C.sub.2 C.sub.6 alkenyl, C.sub.2 C.sub.6 alkynyl, NO.sub.2, NR.sup.4R.sup.5, CN, or CF.sub.3; E is independently O or S; A and B independently are OR.sup.4 or NR.sup.4R.sup.5; each R.sup.4 and R.sup.5 independently are H, C.sub.1 C.sub.6 alkyl, C.sub.2 C.sub.6 alkenyl, C.sub.2 C.sub.6 alkynyl, (CH.sub.2).sub.n aryl, (CH.sub.2).sub.n cycloalkyl, (CH.sub.2).sub.n heteroaryl, or R.sup.4 and R.sup.5 when taken together with the nitrogen to which they are attached complete a 3-to 8-membered ring, optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.

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Patent Owner(s)

Patent OwnerAddress
WARNER-LAMBERT COMPANYMORRIS PLAINS NJ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barvian, Nicole Chantel Ann Arbor, MI 9 65
Connor, David Thomas Ann Arbor, MI 22 209
Dyer, Richard Dennis Ann Arbor, MI 5 13
Johnson, Adam Richard Ann Arbor, MI 4 13
Patt, William Chester Chelsea, MI 19 119

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