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Abstract

Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula ##STR00001## wherein: R.sup.1, R.sup.2, and R.sup.3 independently are hydrogen, halo, hydroxy, C.sub.1 C.sub.6 alkyl, C.sub.1 C.sub.6 alkoxy, C.sub.2 C.sub.6 alkenyl, C.sub.2 C.sub.6 alkynyl, NO.sub.2, NR.sup.4R.sup.5, CN, or CF.sub.3; E is independently O or S; A and B independently are OR.sup.4 or NR.sup.4R.sup.5; each R.sup.4 and R.sup.5 independently are H, C.sub.1 C.sub.6 alkyl, C.sub.2 C.sub.6 alkenyl, C.sub.2 C.sub.6 alkynyl, (CH.sub.2).sub.n aryl, (CH.sub.2).sub.n cycloalkyl, (CH.sub.2).sub.n heteroaryl, or R.sup.4 and R.sup.5 when taken together with the nitrogen to which they are attached complete a 3-to 8-membered ring, optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.

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