Composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
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United States of America Patent
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May 8, 2007
Grant Date -
Oct 23, 2003
app pub date -
Aug 3, 2001
filing date -
Aug 3, 2000
priority date (Note) -
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Abstract
The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH.sub.3--(CH.sub.2).sub.n--CH.sub.2OH or saturated fatty acid CH.sub.3--(CH.sub.2).sub.n--CH.sub.2COOH wherein n is an integer number 8/22, preferably 8/12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH.sub.3(C.sub.nH.sub.2(n-1))--OH or CH.sub.3(C.sub.nH.sub.2(n-1))--COOH wherein n is an integer number 8/22, b) a ternary vehicle or carrier consisting of a C.sub.1/C.sub.4 alkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol.
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