Method of inferring three-dimensional structure of protein
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United States of America Patent
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May 1, 2007
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N/A
app pub date -
Oct 2, 1998
filing date -
Oct 2, 1997
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Expired
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Abstract
A method of predicting a scaffold of a protein comprising a query sequence, using a database which contains environmental information on the side chain of each amino acid residue contained in the amino acid sequence of each reference protein whose three-dimensional structure is known or predictable, and comprising: conducting matching based on the environmental information of each amino acid residue of each reference protein and hydrophobicity or hydrophilicity property of the side chain of each amino acid residue of the query sequence, choosing at least one template protein among the reference proteins that has high similarity in three-dimensional structure to the protein comprising the query sequence, and predicting the scaffold of the protein comprising a query sequence.
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