Substituted pyrazolyl compounds for the treatment of inflammation
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United States of America Patent
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May 1, 2007
Grant Date -
Jun 19, 2003
app pub date -
Sep 19, 2002
filing date -
Sep 19, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to compounds of Formula I: ##STR00001## wherein A is (CH.sub.2).sub.m-Q-(CH.sub.2).sub.n, wherein each CH.sub.2 may be independently substituted with one or more substitution selected from the group consisting of: hydroxy, halo, alkoxy, lower alkyl, amino, aminoalkyl, alkylamino, alkenyl, and alkynyl; B is a 5 or 6 membered heteroaryl, or aryl, optionally saturated, or optionally substituted with R.sup.1, R.sup.2, or R.sup.12; X is selected from the group consisting of: N and C; and Y and Z are independently selected from the group consisting of: N, C, CH, CR.sup.3, S, and O; compositions comprising such compounds, intermediates thereof, methods of making such compounds, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
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