Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis

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United States of America Patent

PATENT NO 7211563
APP PUB NO 20040097457A1
SERIAL NO

10473696

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Abstract

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The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.

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Patent Owner(s)

Patent OwnerAddress
EVOTEC INTERNATIONAL GMBHESSENER BOGEN 7 22419 HAMBURG 22419

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bronner, Gu Gottingen, DE 1 0
Ciossek, Thomas Gottingen, DE 17 33
Eulenberg, Karsten Gottingen, DE 22 40
Hader, Thomas Gottingen, DE 7 8
Steuernagel, Arnd Gottingen, DE 23 80

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