Factor VIII compositions and methods
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United States of America Patent
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May 1, 2007
Grant Date -
May 12, 2005
app pub date -
Oct 20, 2004
filing date -
Oct 31, 2003
priority date (Note) -
Expired
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Abstract
The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It further provides methods for producing such factor VIII mutants. The invention also provides polynucleotides encoding the mutant factor VIII, and methods of treating hemophilia using the polypeptides and polynucleotides of the invention.
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