Recombinant RSV virus expression systems and vaccines
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United States of America Patent
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Apr 17, 2007
Grant Date -
Apr 21, 2005
app pub date -
Oct 25, 2004
filing date -
Sep 26, 1997
priority date (Note) -
Expired
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Abstract
The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
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