Animal with the mass expression of human gene and test method by using the animal
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United States of America Patent
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Apr 10, 2007
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N/A
app pub date -
Oct 5, 2000
filing date -
Oct 5, 1999
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Expired
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Abstract
The present application provides a human gene over-expressing animal, which is a non-human animal carrying a human hematopoietic prostaglandin D.sub.2 synthase gene in its somatic cell chromosome and expressing a large amount of human prostaglandin D.sub.2 synthase, wherein the animal is one obtained through ontogenesis of a totipotency cell of a non-human animal or offspring of the obtained animal, and the totipotency cell is introduced with said synthase gene. The present application also provides a method of using the transgenic animal for testing in vivo activity of a candidate for anti-allergy medicines, sleep-controlling substances and candidates for anti-obesity.
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