Method for detecting a progressive, chronic dementia disease, and corresponding peptides and detection agents

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United States of America Patent

PATENT NO 7202044
APP PUB NO 20040152138A1
SERIAL NO

10476976

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to defined peptides and the quantitative determination thereof in body fluids of patients suffering from progredient chronic dementia, in relation to the concentration of said peptides in a control group. The inventive peptides come from a protein precursor having the corresponding gene, are processed in a specific manner, and are optionally post-translationally modified, especially phosphorylized. An increase in the concentrations of these peptides or the corresponding non-processed protein indicates progredient chronic dementia. Progredient chronic dementia is detected by identifying the peptides and/or the protein individually or in combinations. The invention also relates to the use of said peptides for controlling the course of progredient chronic dementia and for the prognosis of progredient chronic dementia, especially for complementing or replacing mini-mental scores, and for developing therapeutic agents to combat progredient chronic dementia such as Alzheimer's disease.

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Patent Owner(s)

Patent OwnerAddress
DIGILAB INC120 CEDAR STREET CANTON MA 02021

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Heine, Gabriele Hannover, DE 5 51
Hess, Ru Hannover, DE 1 0
Jurgens, Michael Hannover, DE 28 466
Lamping, Norbert Hannover, DE 11 109
Selle, Harmut Hannover, DE 3 31
Zucht, Hans-Dieter Hannover, DE 13 60

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