Heteropolycyclic inhibitors of protein kinases
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Mar 27, 2007
Issued Date -
N/A
app pub date -
Dec 4, 2002
filing date -
Jul 6, 2000
priority date (Note) -
Expired
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Abstract
A method of inhibiting tumor growth is provided, comprising administering an effective dose of a compound of the formula ##STR00001## wherein, independently at each occurrence, w is C or N, v and x are N with H substitution as needed to fulfill open valence sites; y and z are selected from N and C, with H substitution as needed to fulfill open valence sites, with the proviso that each of w, v, x, y and z is not simultaneously C; the ring formed from v, w, x, y and z may be saturated or unsaturated; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected from hydrogen, alkyl, aryl, alkaryl, aralkyl, heteroalkyl, and heteroaryl; wherein any adjacent two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may join together to form a 5, 6 or 7-membered carbocyclic ring or a 5, 6 or 7-membered heterocyclic ring containing at least one atom selected from nitrogen, oxygen and sulfur.
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