Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
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United States of America Patent
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Mar 20, 2007
Grant Date -
Aug 31, 2006
app pub date -
May 2, 2006
filing date -
May 24, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: ##STR00001## including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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