Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent
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United States of America Patent
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Mar 20, 2007
Grant Date -
Nov 14, 2002
app pub date -
Feb 22, 2001
filing date -
Jul 22, 1998
priority date (Note) -
Expired
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Abstract
Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agent, such as a chemokine, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune effector cells, including leukocyte cell types, neutrophils, macrophages, and eosinophils.
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