Polymorphs of a 1-pyrrole derivative, intermediate for the preparation of atorvastatin

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United States of America Patent

PATENT NO 7186848
APP PUB NO 20040249168A1
SERIAL NO

10489686

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Abstract

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The invention relates to new crystalline forms I and II of (4R-cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluoro-phenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester of the Formula (I) and a process for the preparation thereof. The new polymorphs of the present invention are useful pharmaceutical intermediates which can be used in the preparation of the hydroxymethyl-glutaryl coenzyme (HMG-COA) reducing enzyme inhibitor having the INN (International Non-proprietory Name) atorvastatin ##STR00001##

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EGIS GYOGYSZERGYAR RTKERESZTURI UT 30-38 H-1106 BUDAPEST

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barkoczy, Jozsef Budapest, HU 45 669
Bartha, Ferenc Tiszavasvari, HU 10 13
Greff, Zoltan Budapest, HU 13 84
Kotay, Nagy Peter Vac, HU 12 45
Nagy, Kalman Budapest, HU 27 52
Simig, Gyula Budapest, HU 75 181
Szent, Kirallyi Zsuzsa Budapest, HU 3 6
Vereczkeyne, Donath Gyo Budapest, HU 1 1

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