Heterocyclic substituted carbonyl derivatives and their use as dopamine D.sub.3 receptor ligands
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United States of America Patent
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Mar 6, 2007
Grant Date -
Nov 4, 2004
app pub date -
Apr 6, 2004
filing date -
Feb 16, 2001
priority date (Note) -
Expired
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Abstract
The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D.sub.3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D.sub.3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine D.sub.3 receptors.
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