Diastereoselective reductive amination process
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United States of America Patent
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Feb 27, 2007
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app pub date -
Jul 29, 2005
filing date -
Aug 4, 2004
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Abstract
This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with .alpha.-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.
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