Site-specific, covalent bioconjugation of proteins
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United States of America Patent
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Feb 27, 2007
Grant Date -
Jan 31, 2002
app pub date -
Mar 27, 2001
filing date -
Mar 27, 2000
priority date (Note) -
Expired
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Abstract
Heterofunctional crosslinking groups are provided having the formula: ##STR00001## wherein W is a covalent core component; L.sup.1, L.sup.2 and L.sup.3 are independently linking groups; X is a non-covalent or reversibly covalent protein tag binder; Y is a activatable covalent linking group; and Z is a protected or unprotected covalent crosslinking group.
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