Inhibitors for continuous activation for calcineurin
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United States of America Patent
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Feb 27, 2007
Grant Date -
Aug 10, 2006
app pub date -
Oct 7, 2003
filing date -
Oct 8, 2002
priority date (Note) -
Expired
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Abstract
The object of the present invention is to provide a suppressant for neuronal cell death effective for various diseases which inhibits a constitutive active forming of calcineurin and has less side effect. An inhibitor of constitutive active forming of calcineurin, more specifically a drug which inhibits cleavage of calcineurin subunit A (CaNA) by calpain. Examples thereof include peptides having the amino acid sequence of FDGATAAARKEVIRNK (SEQ No. 1) and REESESVLTLKGLTPTG (SEQ No. 2).
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