Substituted pyrimidinones
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United States of America Patent
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Feb 27, 2007
Grant Date -
Dec 2, 2004
app pub date -
Mar 24, 2004
filing date -
Apr 3, 2003
priority date (Note) -
In Force
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Abstract
Disclosed are compounds Formula I ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sub.1, R.sub.2, R.sub.4, and R.sub.5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
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