Protein temperature evaporation-controlled crystallization device and method thereof
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United States of America Patent
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Feb 27, 2007
Grant Date -
Oct 20, 2005
app pub date -
Apr 16, 2004
filing date -
Apr 16, 2004
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A temperature- and evaporation-controlled device for the crystallization of proteins from a protein-containing solution. The device comprises a compartment, such as a microcapillary tube, for holding the solution from which crystals are formed. The compartment is in communication with a cold generating unit, such as a cold finger, that maintains a temperature lower than the temperature of the compartment thereby causing de-watering of the solution. A vacuum pump can be attached to the device to reduce vapor pressure to further promote de-watering of the solution. The device can be used terrestrially or in a microgravity environment, such as in outer space, for formation of high quality protein crystals.
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