VLA-4 inhibitor compounds
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Feb 20, 2007
Grant Date -
Nov 18, 2004
app pub date -
Feb 26, 2004
filing date -
Jun 30, 1999
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Compounds that selectively inhibit the binding of ligands to .alpha.4.beta.1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: ##STR00001## As selective inhibitors of VLA-4 mediated cell adhesion, compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, such conditions as inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting VLA-4 mediated cell adhesion and methods of treating conditions associated with LA-4 mediated cell adhesion.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully