Aryl-substituted alicyclic compound and medical composition comprising the same
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United States of America Patent
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Feb 13, 2007
Grant Date -
Jun 3, 2004
app pub date -
Mar 14, 2002
filing date -
Mar 19, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An aryl-substituted alicyclic compound of the formula (I): ##STR00001## wherein U is 1,4,5,6-tetrahydropyrimidin-2-yl, etc., A is phenylene, etc., B is piperidine-1,4-diyl, etc., Z is --CONH--, etc., R.sup.3 is hydrogen, etc., R.sup.5 is hydrogen, aryl, etc., R.sup.6 is a mono-substituted amino (e,g., benzyloxycarbonylamino), R.sup.7 is hydrogen, etc., and a process for preparation thereof, and a pharmaceutical composition containing the same. The compound of the present invention has a high selectivity for .alpha.v.beta.3 integrin, and exhibits a potent inhibitory activity thereto, and hence, it is useful as a preventive or/and a therapeutic agent for a disease in which .alpha.v.beta.3 integrin is involved.
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