CD40:CD154 binding interrupter compounds and use thereof to treat immunological complications
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United States of America Patent
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Feb 6, 2007
Grant Date -
Apr 8, 2004
app pub date -
Feb 28, 2003
filing date -
Apr 24, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
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