Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria

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United States of America Patent

PATENT NO 7169903
APP PUB NO 20030228322A1
SERIAL NO

10323903

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-positive bacteria in vivo. The invention also provides human, humanized and chimeric antibodies. The invention also sets forth the heavy chain and light chain variable regions of an antibody within the invention.

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Patent Owner(s)

Patent OwnerAddress
BIOSYNEXUS INCORPORATED9298 GAITHER ROAD GAITHERSBURG MD 20877

International Classification(s)

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  • 2002 Application Filing Year
  • C12P Class
  • 2781 Applications Filed
  • 477 Patents Issued To-Date
  • 17.16 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances200220032004200520062007200820092010201120122013201420152016201720180255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fischer, Gerald Walter Bethesda, MD 9 99
Foster, Simon J Sheffield, GB 11 45
Kokai-Kun, John Fitzgerald Frederick, MD 6 47
Schuman, Richard F Gaithersburg, MD 19 279
Stinson, Jeffrey R Brookeville, MD 24 724

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Patent Citation Ranking

  • 10 Citation Count
  • C12P Class
  • 13.15 % this patent is cited more than
  • 18 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges662885730215128322801 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +020406080100120140160180200220240260280300320

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